Transient Myeloproliferative Disorder and Down Syndrome : Is there a Link ? = إضطراب التكاثري النقبي المؤقت و متلازمة داونهل ثمة رابط ؟
نویسندگان
چکیده
منابع مشابه
Transient Myeloproliferative Disorder in Neonate with Suspected Down Syndrome
A female with suspected Down syndrome was born by vaginal delivery at 37 weeks 2 days’ gestation to a mother with a history of Type A2 gestational diabetes mellitus. Routine prenatal testing consisted of a non-invasive screening test for aneuploidy. Results, presented in Table 1, indicated an aneuploidy for trisomy of chromosome 21, indicating an increased risk for Down syndrome. Prenatal confi...
متن کاملTransient myeloproliferative syndrome associated with Down syndrome.
production run with hydrogen peroxide and rinsed with deionized water. As moisture may remain in the less accessible points of the system (bends and filters), Kathon CG is added to the rinse water to ensure a completely sterile process. As a result of this finding, the company marketing the cream compensated the patient and changed the procedure for cleaning the machinery, replacing the Kathon ...
متن کاملDown's syndrome with transient myeloproliferative disorder.
Children with Down's syndrome are at an increased risk for development of several hematological disorders like acute leukemia, acute myelofibrosis of childhood and transient myeloproliferative disorder (TMD)(1). Transient myeloproliferative disorder is recognized shortly after birth or in neonatal period and is characterized by leukocytosis and thrombocytopenia, which resolves spontaneously in ...
متن کاملAnalysis of GATA1 mutations in Down syndrome transient myeloproliferative disorder and myeloid leukemia.
Children with Down syndrome (DS) up to the age of 4 years are at a 150-fold excess risk of developing myeloid leukemia (ML-DS). Approximately 4%-5% of newborns with DS develop transient myeloproliferative disorder (TMD). Blast cell structure and immunophenotype are similar in TMD and ML-DS. A mutation in the hematopoietic transcription factor GATA1 is present in almost all cases. Here, we show ...
متن کاملTransient neonatal myeloproliferative disorder without Down syndrome and detection of GATA1 mutation.
Transient myeloproliferative disorder is a form of self-limited leukemia that occurs almost exclusively in neonates with Down syndrome. The authors report an unusual case of a newborn without constitutional trisomy 21 who developed undifferentiated leukemia and subsequently achieved clinical and molecular remission without chemotherapy. Cytogenetics and molecular analysis have shown trisomy 21 ...
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ژورنال
عنوان ژورنال: Sultan Qaboos University Medical Journal
سال: 2012
ISSN: 2075-0528
DOI: 10.12816/0003177